TALE & TALENs

Affordable and fast turnaround custom services for designing, creating and validating TALENs, TALE-TFs and other TAL effectors-based targeted genomic modification tools.

TAL effectors have been utilized to create site-specific gene-editing tools by fusing target sequence-specific TAL effectors to nucleases(TALENs), transcription factors (TALE-TFs) and other functional domains. These fusion proteins can recognize and bind chromosome target sequences specifically and execute their gene-editing functions, such as gene knockout, knockin (with donor plasmid), modification, activation, repression and more. Unlike zinc fingers’ nucleotide triplet recognition, TAL effector domains recognize single nucleotides, which allows researchers to be able to specifically target whatever sequence they want.

Advantages:

• Targeting any gene in any cell
• Highly sequence-specific genome editing
• For gene knockout, knockin, mutagenesis, activation, repression and more
• Flexible TAL effector design of binding and functional domains, such as TALEN and TALE-TF

TAL effector nuclease services

TALENs are cutting-edge genome engineering tools that are made by fusing a tailor-made TAL effector DNA-binding protein to the FokI nuclease domain. TALENs can induce site-specific double-strand breaks (DSBs) in DNA at any user-defined genomic location, which leads to targeted modification of the genome. Recent studies have established TALENs as an innovative tool for targeted genome editing in diverse cell lines and organisms.